NEUROBIOLOGY OF STRESS
AND ADDICTION
Vulnerability to stress-related disorders such as anxiety, depression, and addiction can vary with sex and gender. This may be driven by sex differences in brain structure, chemistry, and circulating hormones. Adolescence is a period of neural plasticity during which stressful experiences and exposure to substances such as alcohol may modulate endocrine systems, thus interfering with normal neural remodeling and development of sexually dichotomous behaviors.
Our research uses rodent models to investigate the neural, hormonal, and behavioral determinants of addiction, and how susceptibility to stress-related disorders may be shaped around the time of birth and during adolescent development.
Fig. 1: A new cell in old age. A newly differentiated and myelinating oligodendrocyte (green) located in the Pirriform cortex of a middle-aged mouse. Image at 60X magnification was acquired using confocal microscopy and cell was labeled with green flourescent protein (GFP, green) and aspartoacylase (ASPA, pink) antibodies using immunohistochemistry.